Review on drug delivery system for phytomedicine through mechanism of encapsulation

Natural products have limitation in the bioavailability of active components because numbers reasons which includes poor solubility ingredient, stability due to gastric and colonic acidity, metabolism by effect gut microflora, absorption across intestinal wall, efflux mechanism first-pass metabolic effects these factors make failure clinical trials efficacy natural phytochemicals used for human consumption both cell culture preclinical animal model systems is distinctly addressed various researchers. Over past decades, extraordinary advances been made successfully on development novel drug delivery encapsulation plant metabolites including organic, inorganic hybrid nanoparticles .Various nanosystems advanced biotechnology introduced improve therapeutic efficacy, safety market appeal nutraceuticals phytochemicals, liposomes, polymeric micelles, nanoparticles, phytosomes. The formulas are confirmed benefits over conventional previously manner solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, physical chemical degradation.